| Customization: | Available |
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| CAS No.: | 1159861-00-3 |
| Feature: | Stocked |
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| Product Name: | PNC-27 | Cas No. | peptides |
| Purity: | 99% | Formula weight: | 579.3 |
| Package: | Foil Bag | Molecular formula: | C30H54N6O5 |
| MOQ: | 1 Gram or 1 Box | EINECS: | 203-405-2 |
| delivery: | 8-12days | Grade Standard | Top Quality |
| Sample | Availiable | Shelf Life | 2 Years |
PNC-27 is a synthetic peptide primarily used for its anti-cancer properties. It is designed to target and bind to the HDM-2 protein, which is overexpressed in cancer cells. This binding leads to the formation of pores in the cancer cell membranes, resulting in cell necrosis and death. Importantly, PNC-27 selectively targets cancer cells without harming normal cells, making it a promising candidate for cancer therapy.
The primary use of PNC-27 is in cancer research, where it has shown potential in treating various types of cancer, including acute myeloid leukemia (AML), breast cancer, and pancreatic cancer. Its mechanism of action involves binding to HDM-2 in a p53 peptide-like structure, which disrupts the function of HDM-2 and leads to the activation of p53, a tumor suppressor protein. This activation triggers pathways that result in the death of cancerous cells.
Ongoing research continues to explore the applications and efficacy of PNC-27 in different cancer types, aiming to provide effective and less toxic treatment options for cancer patients
PNC-27 is an anti-cancer peptide that has shown significant promise in cancer research. It is designed to bind to the HDM-2 protein, which is overexpressed in cancer cells. This binding leads to the formation of pores in the cancer cell membrane, resulting in cell necrosis and death.
PNC-27 is composed of amino acid residues 12-26 from the HDM-2 binding domain of the p53 protein, linked to a membrane-penetrating sequence known as the membrane residency peptide (MRP). This structure allows PNC-27 to infiltrate cancer cells and exert its cytotoxic effects. It selectively targets cancer cells without harming normal cells, making it a potentially safer treatment option.
PNC-27 has demonstrated effectiveness against a wide range of cancer types, including acute myeloid leukemia (AML), breast cancer, pancreatic cancer, melanoma, and others. In studies, PNC-27 has been shown to induce nearly 100% cell killing in cancer cells, while having no effect on healthy cells.
Ongoing research continues to explore the potential of PNC-27 in different cancer models. It has been tested in both in vitro and in vivo studies, showing promising results in reducing tumor growth and prolonging survival in animal models. The peptide's ability to target cancer cells through a p53-independent pathway further enhances its therapeutic potential.
Overall, PNC-27 represents an innovative approach in cancer treatment, offering a targeted and potentially less toxic alternative to traditional chemotherapy.
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Q1: About the after-sale service of products
A: After purchasing the products from our factory, we have A professional technical team and after-sales team to serve you and solve all your problems in the future
Q2: Can I get some samples?
A: Yes, we can provide samples, but the customer will pay the freight.
Q3: How do I start paying?
Payment can be made by Bitcoin,wire transfer or Western Union
Q4: How to confirm product quality before placing an order?
A: You can get free samples of some products. You just have to pay the shipping fee
Q5: What is your MOQ?
A: The minimum quantity we can order is 1kit.
Q6: How to customize the product??
A:You can send us your product specifications and requirements and we will produce products according to your requirements.
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