Customization: | Available |
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CAS No.: | Peptides |
Formula: | C43h66n12o12s2 |
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Basic information
Product Name: | Reta | Cas No. | peptides |
Purity: | 99% | Formula weight: | |
Package: | Box | Molecular formula: | |
MOQ: | 1 Gram or 1 Box | EINECS: | 200-001-8 |
Transportation: | By Air | Grade Standard | Top Quality |
Sample | Availiable | Shelf Life | 2 Years |
Description:
Reta is the newest GL agonist and was approved by the FDA as a once-weekly injection for the treatment of T2DM in late 2017. The peptide is chemically similar to sema,tirz, with the inclusion of two structural modifications (Lau, Bloch, et al., 2015). The first is the replacement of Gly with the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib) at position 2. The second is the attachment of octadecanoic diacid to the side chain of Lys-26 through a short polyethylene glycol (PEG) spacer and a γ-glutamic acid linker. The amino acid substitution renders the peptide more resistant to DPP-4 compared to lira, and the presence of the 18-carbon fatty acid moiety results in a high binding affinity for serum albumin, which translates to a half-life of approximately 7 days in humans
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